职业与环境危害因素检测与评价研究室

发布时间:2022-07-29 发布者:公共卫生学院 浏览次数:

科研团队信息登记表

一 基本信息

1. 团队名称:职业与环境危害因素检测评价研究室

2. 团队负责人:梅勇

3. 团队成员梅勇,宋世震,常薇,郭振中,吴磊,赵琴,李诚予,江明頔,顾缨缨

二 科研情况

  1. 科研团队简介:(基本介绍,研究方向,内容,突出成果等。)

职业与环境危害因素检测与评价研究室是“职业危害识别与控制湖北省重点实验室”的重要组成部分和研究平台,目前主要研究方向:环境与职业危害因素检测与评价光电生物传感器检测、单细胞分析方法、样品前处理新技术、工效学、职业与环境卫生标准研制。

 “职业接触苯的生物限值标准制定”获得湖北省科技进步奖二等奖,“重点制造行业卫生防护距离标准制定”、“职业接触丙酮、二甲苯的生物限值和检验技术研制与应用”获湖北省科技进步三等奖。承担国家标准制定6项,获得国家发明专利5项,近3年发表影响因子大于10的高水平论文9篇,主编本科教材1部。




  1. 平台设施:(科研平台的条件、基础设施,场地,面积等)

平台拥有气相色谱仪、液相色谱仪、液相色谱质谱仪、原子吸收光谱仪、原子荧光仪、凝胶电泳仪、紫外可见分光光度、电化学工作站、单光子计数功能的荧光分光光度计等科研设备。

  1. 5年科研项目:(项

  2. 目名称,编号,起止时间,来源,负责人,金额)

1)基于光镊辅助荧光成像和发光限域型808 nm激发上转换FRET纳米探针标记的单细胞分析方法研究,国家自然科学基金青年项目,主持,2020.01-2022.12,李诚予

2)基于花粉固相萃取和稳定同位素标记的LC-MS/MS方法在尿样中多种苯系物代谢产物同时检测的应用(81903366),国家自然科学基金青年项目,主持,2020.01-2022.12,赵琴

3)基于功能化金属有机框架材料的光电免疫传感平台的构建及其应用研究,81973097,国家自然科学基金面上项目,2020.01-2022.12,第二单位,梅勇,郭振中

4)人工智能超声联合循环MicroRNA检测筛查乳腺癌关键技术研究,2020BCB022,湖北省重点研发计划项目,湖北省科技厅,2020.8 - 2022.7,第二单位,郭振中

5)湖北大冶重金属高风险区人群健康监测,生态环境部科研计划项目,国家生态环境部,主持,2018.5-2020.5,梅勇

6)湖南花垣环境健康风险哨点监测,生态环境部科研计划项目,国家生态环境部,主持,2018.5-2020.5,梅勇

7)湖北大冶重金属高风险区人群健康监测,生态环境部科研计划项目,国家生态环境部,主持,2019.6-2021.6,梅勇

8)湖北大冶重金属高风险区人群健康评估,生态环境部科研计划项目,国家生态环境部,主持,20202020.6-2022.6,梅勇

9)新冠肺炎等重大传染病应急处置与卫生应急物储备对策研究,武汉市卫生健康委员会,主持,2020.9-2023.9,梅勇

10)武汉科技大学国家“优青”培育计划项目,主持,2020.01-2022.12,李诚予



11)无标签水凝胶传感器在阿尔茨海默病早期识别的方法应用与研究,G20200227010,高端外国专家引进计划,科技部,主持2020.05-2022.05,郭振中

12)纸基微流控纳米生物传感器在环境中的基础与应用研究,G20190227002,外国专家项目计划,科技部,主持,2019.01-2019.12,郭振中

13)磁性混合模式萃取介质的制备及其在尿液中多种苯系物代谢产物同时检测的应用(2018CFB202),湖北省自然科学基金青年项目,主持, 2018.01-2019.12,赵琴

14)空降兵踝关节保护支具对踝关节周围肌肉遥测肌电测试的研究,中国人民解放军95829部队医院,主持,2021~2022年,吴磊

15)湖北省医院-社区-家庭一体化慢病管理模式探讨,施维雅(天津)制药有限公司,主持,2019~2021年,吴磊

4. 代表性文章:(论文题目,作者,期刊,年,分区,影响因子)

1. Zhiyuan Hou; Jun Zheng; Chengfang Zhang; Ting Li; Die Chen; Liang Hu; Junrui Hu; Bing Xiong; Huarong Ye; Nicole Jaffrezic-Renault; Zhenzhong Guo; Direct ultrasensitive electrochemical detection of breast cancer biomarker-miRNA-21 employing an aptasensor based on a microgel nanoparticle composite, Sensors & Actuators: B. Chemical, 2022, 367: 132067IF9.221,一区

2.Ziyu Huang; Hao Chen; Huarong Ye; Zixuan Chen; Nicole Jaffrezic-Renault; Zhenzhong Guo; An ultrasensitive aptamer-antibody sandwich cortisol sensor for the noninvasive monitoring of stress state, Biosensors and Bioelectronics, 2021, 190: 113451IF12.545,一区

3.Zhi Zhao; Changfu Huang; Ziyu Huang; Fengjuan Lin; Qinlin He; Dan Tao; Nicole Jaffrezic-Renault; Zhenzhong Guo; Advancements in electrochemical biosensing for respiratory virus detection: A review, Trends in Analytical Chemistry, 2021, 139: 116253IF14.908,一区,封面论文

4. Mengsha Ye; Mingdi Jiang; Jing Cheng; Xuanying Li; Ziwei Liu; Weiying Zhang; Samuel M. Mugo; Nicole Jaffrezic-Renault; Zhenzhong Guo; Single-layer exfoliated reduced graphene oxide-antibody Tau sensor for detection in human serum; Sensors & Actuators: B. Chemical, 2020, 308: 12769IF9.221,一区

5. Xuan Wu; Tingyu Xiao; Zhang Luo; Rongxiang He; Yiping Cao; Zhenzhong Guo; Weiying Zhang; Yong Chen; A micro-/nano-chip and quantum dots-based 3D cytosensor for quantitative analysis of circulating tumor cells, Journal of Nanobiotechnology, 2018, 16:65IF9.429,一区

6.Cheng-Yu Li*, Bei Zheng, Jiang-Tao Li, Jia-ling Gao, Yu-Heng Liu, Dai-Wen Pang, Hong-Wu Tang*. Holographic Optical Tweezers and Boosting Upconversion Luminescent Resonance Energy Transfer Combined Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas12a Biosensors. ACS Nano2021, 15, 8142-8154.自然指数期刊,SCI一区,IF: 18.027

7.Cheng-Yu Li*, Jun-Xian Liu, Liu Yuheng, Jia-Ling Gao, Ya-Ling Chen, Jing-Wei He, Meng-Kun Xin, Da Liu, Bei Zheng, Xiaoming Sun. Upconversion Luminescence-Initiated and GSH-Responsive Self-Driven DNA Motor for Automatic Operation in Living Cells and In Vivo. Analytical Chemistry 2022, 94, 5450-5459.(自然指数期刊,SCI一区,IF: 8.008

8.Cheng-Yu Li*, Jun-Xian Liu, Meng-Kun Xin, Jing-Wei He, Ya-Ling Chen. A Self-Made Optical Tweezers Integrated Upconversion Luminescence Confocal Scanning Instrument Enables Stable and Noninvasive Long-Term In Situ Imaging a Single Suspension Cell Under Exceptionally Efficient Luminescent Resonance Energy Transfer Sensing. Analytical Chemistry 2022, 94, 6909-6917.(自然指数期刊,SCI一区,IF: 8.008

9. Jia-Ling Gao, Liu Yuheng, Jun-Xian Liu, Hong-Wu Tang, Cheng-Yu Li*. A Photoresponsive and Metal-Organic Framework Encapsulated DNA Tetrahedral Entropy-Driven Amplifier for High-Performance Imaging Intracellular MicroRNA. Analytical Chemistry 2021, 93, 16638-16645. (自然指数期刊,SCI一区,IF: 8.008

10.Cheng-Yu Li*, Bei Zheng, Li-Li Lu, Wen-Kai Fang, Ming-Qiu Zheng, Jia-Ling Gao, Liu Yuheng, Dai-Wen Pang, Hong-Wu Tang*. Biomimetic Chip Enhanced Time-Gated Luminescent CRISPR-Cas12a Biosensors under Functional DNA Regulation. Analytical Chemistry 2021, 93, 12514-12523.(自然指数期刊,SCI一区,IF: 8.008

11.Cheng-Yu Li, Ya-Feng Kang, Chu-Bo Qi, Bei Zheng, Ming-Qiu Zheng, Chong-Yang Song, Zhen-Zhong Guo, Yi Lin, Dai-Wen Pang, Hong-Wu Tang*. Breaking Through Bead-Supported Assay: Integration of Optical Tweezers Assisted Fluorescence Imaging and Luminescence Confined Upconversion Nanoparticles Triggered Luminescent Resonance Energy Transfer (LRET). Analytical Chemistry 2019, 92, 7950-7957.(自然指数期刊,SCI一区,IF: 8.008

12.Cheng-Yu Li, Di Cao, Chu-Bo Qi, Ya-Feng Kang, Chong-Yang Song, Dang-Dang Xu, Bei, Zheng, Dai-Wen Pang, Hong-Wu Tang*. Combining Holographic Optical Tweezers with Upconversion Luminescence Encoding: Imaging-Based Stable Suspension Array for Sensitive Responding of Dual Cancer Biomarkers. Analytical Chemistry2018, 90, 2639-2647.(自然指数期刊,SCI一区,IF: 8.008

13.Cheng-Yu Li, Di Cao, Ya-Feng Kang, Yi Lin, Ran Cui, Dai-Wen Pang, Hong-Wu Tang*. Fluorescence Detection of H5N1 Virus Gene Sequences Based on Optical Tweezers with Two-Photon Excitation Using a Single Near Infrared Nanosecond Pulse Laser. Analytical Chemistry, 2016, 88, 4432-4439.(自然指数期刊,SCI一区,IF: 8.008

14.Cheng-Yu Li, Ting Zhang, Ya-Feng Kang, Chu-Bo Qi, Bei Zheng, Chun-Miao Xu, Yi Lin, Dai-Wen Pang*, Hong-Wu Tang*. Incorporating luminescence-concentrating upconversion nanoparticles and DNA walkers into optical tweezers assisted imaging: a highly stable and ultrasensitive bead supported assay. Chemical Communications 2020, 56, 6997-7000.(自然指数期刊,SCI一区,IF: 6.065

15.Cheng-Yu Li, Di Cao, Chong-Yang Song, Chun-Miao Xu, Xu-Yan Ma, Zhi-Ling Zhang, Dai-Wen Pang, Hong-Wu Tang*. Integrating Optical Tweezers with Up-converting Luminescence: A Non-amplification Analytical Platform for Quantitative Detection of MicroRNA-21 Sequences. Chemical Communications2017, 53, 4092-4095.(自然指数期刊,SCI一区,IF: 6.065

16.Cheng-Yu Li, Bei Zheng, Ya-Feng Kang#, Hong-Wu Tang*, Dai-Wen Pang*. Integrating 808 nm Light-Excited Upconversion Luminescence Powering with DNA Tetrahedron Protection: An Exceptionally Precise and Stable Nanomachine for Intracellular MicroRNA Tracing. ACS Sensors 2021, 5, 199-207.SCI一区,IF: 9.618

17. Jia-Ling Gao, Yu-Heng Liu, Bei Zheng, Jun-Xian Liu, Wen-Kai Fang, Da Liu, Xiao-Ming Sun, Hong-Wu Tang, Cheng-Yu Li*. Light-Activated and Self-Driven Autonomous DNA Nanomachine Enabling Fluorescence Imaging of MicroRNA in Living Cells with Exceptional Precision and Efficiency. ACS Applied Materials & Interfaces 2021, 13, 31485-31494.SCI一区,IF: 10.383

18. Yu-Heng Liu, Jia-Ling Gao, Jun-Xian Liu, Da Liu, Wen-Kai Fang, Bei Zheng, Hong-Wu Tang*, Cheng-Yu Li*. Photo-gated and self-powered three-dimensional DNA motors with boosted biostability for exceptionally precise and efficient tracing of intracellular survivin mRNA. Biosensors and Bioelectronics 2021, 190, 113445.SCI一区,IF: 12.545

19.Cheng-Yu Li*, Bei Zheng, Yu-Heng Liu, Jia-Ling Gao, Ming-Qiu Zheng, Dai-Wen Pang, Hong-Wu Tang*. A boosting upconversion luminescent resonance energy transfer and biomimetic periodic chip integrated CRISPR/Cas12a biosensor for functional DNA regulated transduction of non-nucleic acid targets. Biosensors and Bioelectronics 2020, 169, 112650.SCI一区,IF: 12.545

20.Cheng-Yu Li, Di Cao, Chu-Bo Qi, Hong-Lei Chen, Ya-Tao Wan, Yi Lin, Zhi-Ling Zhang, Dai-Wen Pang, Hong-Wu Tang*. One-step Separation-free Detection of Carcinoembryonic Antigen in Whole Serum: Combination of Two-Photon Excitation Fluorescence and Optical Trapping. Biosensors and Bioelectronics2017, 90, 146-152.SCI一区,IF: 12.545

21.Yu-Heng Liu, Jun-Xian Liu, Jia-Ling Gao, Hong-Wu Tang, Cheng-Yu Li*. A dual DNA tetrahedrons and MnO2 nanosheets sustained entropy-driven DNA amplifier enables high-performance operation in live cells and bodies under a light-gated manner. Chemical Engineering Journal 2022, 438, 135590.SCI一区,IF: 16.744

22.Cheng-Yu Li*, Jun-Xian Liu, Yu-Heng Liu, Jia-Ling Gao, Bei Zheng, Da Liu. An Exceptional and Universal DNA Walker Amplified “One-to-Many” CRISPR/Cas12a-Mediated Fluorescent Biosensor for Ultrasensitive Detection of Non-DNA Biomarkers. Sensors and Actuators B: Chemical 2022, 361, 131743.SCI一区,IF: 9.221

23.Cheng-Yu Li, Ya-Feng Kang, Bei Zheng, Chun-Miao Xu, Chong-Yang Song, Dai-Wen Pang, Hong-Wu Tang*. Using optical tweezers to construct an upconversion luminescent resonance energy transfer analytical platform. Sensors and Actuators B: Chemical 2019, 282, 790-797.SCI一区,IF: 9.221

24. Li-Li Lu, Chao-Zhi Li, Heng-Zhong Guo, Da Liu, Hong-Wu Tang, Bei Zheng, Cheng-Yu Li*. Monitoring of viral myocarditis injury using an energy-confined upconversion nanoparticle and nature-inspired biochip combined CRISPR/Cas12a-powered biosensor.Analytica Chimica Acta 2022, 1195, 339455.SCI二区topIF: 6.911


三 学术骨干

  1. 姓名,个人简介(研究方向,项目,文章,获奖 等等),照片。



梅勇,医学博士,教授,硕士生导师。国家卫生健康标准委员会职业健康标准专业委员会委员、全国高等学校卫生检验与检疫专业规划教材评审委员、湖北省预防医学会劳动卫生与职业病专业委员会副主委、武汉市预防医学会劳动卫生与职业病专业委员会副主委、湖北省预防医学会卫生检验专业委员会常委,主持国家卫生部科研项目4项、国家环保部科研专项6项,主持横向科研项目30余项,荣获湖北省科技进步二等奖1等奖1项;主编本科教材和研究生教材2部;主持和参与修订中华人民共和国国家职业卫生标准8项;发表科研论文130余篇。



武汉科技大学职业危害识别与控制湖北省重点实验室执行主任,医学院和公卫学院院长助理。法国里昂大学博士和初级学者研究员,英国基尔大学访问学者。主要研究方向为纳米生物传感。

李诚予男,湖北省“楚天学子”,副教授,硕士生导师。本科毕业于华中师范大学,获化学和物理学双学士学位。博士毕业于武汉大学分析化学专业。主要从事生物传感器在医学检验方面的研究工作。目前主持国家自然科学基金项目一项,武汉科技大学国家“优青”培育计划项目一项,以第一作者和通讯作者在SCI一区期刊ACS Nano (自然指数期刊)、Analytical Chemistry (自然指数期刊)、Chemical Communications (自然指数期刊)、ACS SensorsACS Applied Materials & InterfacesBiosensors and BioelectronicsChemical Engineering JournalSensors and Actuators B: Chemical等上发表研究型论文20篇。


赵琴,副教授,主要以分离科学与技术和生物标志物的检测为研究方向,研究内容涉及固相萃取、磁固相萃取、分散液液微萃取等样品前处理技术,新型萃取材料的开发与应用,研究对象包括食品、环境和生物等复杂样品。第四届全国大学生生命科学创新创业大赛一等奖,教育部高等学校生物技术、生物工程类专业教学指导委员会,首届“人卫杯”全国高等学校卫生检验与检疫专业青年教师教学授课竞赛二等奖,教育部高等医学技术类业教学指导委员会。


吴磊,男,博士,副教授,武汉科技大学医学院劳动卫生与环境卫生学硕士生导师。毕业于华中科技大学同济公共卫生学院劳动卫生与环境卫生学专业,现任湖北预防医学会劳动卫生与职业病学会理事,中国职业安全健康协会职业卫生专业委员会,常务委员;全国卫生产业企业管理协会职业与环境健康分会,常务理事。2014年至2015年以访问学者身份赴美国华盛顿州劳工部安全与健康预防评价研究实验室(Safety & Health Assessment & Research for Prevention, SHARP)和美国圣马丁大学访问学习。2018年承担湖北省重点实验室“湖北省制造业工人职业性肌肉骨骼疾患危害影响评估与工效学研究重点项目,发表论文二十余篇,获得专利三项。目前,带领研究团队创建职业健康管理数据中心网络平台,现从事职业健康风险危险度评价和肌肉骨骼疾患的工效学预防和康复研究。




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