廖静伶
发布人:公共卫生学院  发布时间:2019-12-13   浏览次数:12

公共卫生学院教师名录

姓名:廖静伶

职称:副教授

讲授课程:分子流行病学

研究方向:慢性病与神经退行性疾病研究

社会兼职

教学研究项目:(课题来源、名称、编号、年限、本人作用)


教学论文:(作者、题目、刊物名称、时间、卷(期)、起至页码)


科研项目:(课题名称、来源、编号、年限、本人所起作用)

一、

项目名称:帕金森病致病蛋白LRRK2ROC结构域GTP水解抑制机制与结构生物学研究(31500596)主持

项目来源:国家自然科学基金委

起止时间:2016.01-2018.12

科研经费:20万(直接经费)

二、

项目名称:LRRK2IIPAKs的相互作用对神经元突起生长调节的影响(81971196)主持

项目来源:国家自然科学基金委

起止时间:2020.01-2023.12

科研经费:55万(直接经费)

科研论文:(作者、题目、刊物名称、时间、卷(期)、起至页码)

  1. Chun-Xiang Wu*, Jingling Liao*, Yangshin Park, Xylena Reed , Victoria A. EngelNeo C. Hoang, Yuichiro Takagi , Steven M. Johnson, Mu Wang, Mark Federici , R. Jeremy Nichols , Ruslan Sanishvili , Mark R. Cookson , and Quyen Q. Hoang Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics. J. Biol. Chem. 2019 Feb. 22; 294(15): 5907-5913. (IF: 4.1) (* Co-first author)

  2. Xiaorong HuangChunxiang WuYangshin ParkXuwei LongQuyen Q. Hoang, and Jingling Liao#The Parkinson's disease–associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2. The Faseb J 2018 Dec. 18; 33 (4): 4814-4823. (IF: 5.6) (# corresponding author)

  3. Jingling Liao#, Quyen Q. Hoang# Roco Proteins and the Parkinson’s Disease-Associated LRRK2. Int J Mol Sci 2018 Dec. 03; 19 (12). (IF: 3.8) (# Corresponding author)

  4. 4 Matsumoto S, Miyano N, Baba S, Liao J, Kawamura T, Tsuda C, Takeda A, Yamamoto M, Kumasaka T, Kataoka T, Shima F. Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal. Sci Rep. 2016 May 16;6:25931. (IF: 5.6)

  5. Liao, J., Wu, CX., Burlak, C., Zhang, S., Sahm H, Wang M, Zhang, ZY., Vogel, KW., Federici, M., Riddle, SM., Nichols, RJ., Liu, D., Cookson, MR., Stone, TA. and Hoang, QQ. Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain.Proc Natl Acad Sci U S A. 2014, 111(11):4055-60. (IF: 9.7)


  1. Edayathumangalam, R., Wu, R., Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC, Hoang QQ, Belitsky BR, Petsko GA, Ringe D, Liu D. Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.Proc Natl Acad Sci U S A. 2013, 110(44):17820-5. (IF: 9.8)


  1. Shima F, Yoshikawa Y, Ye M, Araki M, Matsumoto S, Liao J, Hu L, Sugimoto T, Ijiri Y, Takeda A, Nishiyama Y, Sato C, Muraoka S, Tamura A, Osoda T, Tsuda K, Miyakawa T, Fukunishi H, Shimada J, Kumasaka T, Yamamoto M, Kataoka T. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.Proc Natl Acad Sci U S A. 2013, 110(20):8182-7. (IF: 9.8)


  1. Wang W, Perovic I, Chittuluru J, Kaganovich A, Nguyen LT, Liao J, Auclair JR, Johnson D, Landeru A, Simorellis AK, Ju S, Cookson MR, Asturias FJ, Agar JN, Webb BN, Kang C, Ringe D, Petsko GA, Pochapsky TC, Hoang QQ.A soluble alpha-synuclein construct forms a dynamic tetramer.”Proc Natl Acad SciU S A. 2011, 108(43):17797-802. (IF: 9.9)


  1. Matsumoto K, Shima F, Muraoka S, Araki M, Hu L, Ijiri Y, Hirai R, Liao J, Yoshioka T, Kumasaka T, Yamamoto M, Tamura A, Kataoka T.Critical Roles of Interactions among Switch I-preceding Residues and between Switch II and Its Neighboring α-Helix in Conformational Dynamics of the GTP-bound Ras Family Small GTPases.”Journal of Biological Chemistry. 2011, 286(17): 15403–15412. (IF: 5.2)


  1. Shima F, Ijiri Y, Muraoka S, Liao J, Ye M, Araki M, Matsumoto K, Yamamoto N, Sugimoto T, Yoshikawa Y, Kumasaka T, Yamamoto M, Tamura A, Kataoka T. “Structural basis for conformationaldynamics of GTP-bound Ras protein.”Journal of Biological Chemistry. 2010, 285(29): 22696–22705 (*Co-first author) (IF: 5.4)


  1. Liao J, Shima F, Araki M, Ye M, Muraoka S, Sugimoto T, Kawamura M, Yamamoto N, Tamura A, Kataoka T.“Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics” Biochemical and Biophysical Research Communications, 2008, 369:327-332 (IF: 2.8)


  1. Ye M, Shima F, Muraoka S, Liao J, Okamoto H, Yamamoto M, Tamura A, Yagi N, Ueki T, Kataoka T.“Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases”Journal of Biological Chemistry. 2005, 280(35); 31267-31275. (IF: 6.5)

荣誉与获奖:(奖项名称、授予单位、署名次序、时间)